• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
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  • 优先权
    • 专利摘要:
    The invention relates to a device (1; 3; 4) for detecting the withdrawal of medicaments (23) from a medicament blister (2), comprising a base body (10) for receiving the medicament blister (2) with a base surface (11) which belongs to Plant to which the pockets (21) of the blister (2) closing electrically conductive film (22) is formed, wherein the base body (10) in the region of the pockets (21) of the blister (2) holes (12; 32; 42) , which are formed for the passage of the in the pockets (21) of the blister (2) located drugs (23), - each hole (12) respectively in the region of one of the pockets (21) is arranged, - wherein in the region of each Holes (12) at least one coil (13, 14, 15; 33, 34, 35, 43) is arranged, which wraps around the respective hole (12), in particular exclusively the respective hole (12), and - wherein a detector unit ( 16, 36, 46) provided by means of one of the coils (13, 14, 15) in the region of one or more L. öcher (12) generates an electric and / or magnetic field and the voltage or the current at least one of the hole (12), in particular exclusively this hole (12), looping around coils (13, 14, 15) evaluates.
    公开号:AT515453A2
    申请号:T50173/2014
    申请日:2014-03-10
    公开日:2015-09-15
    发明作者:
    申请人:Seibersdorf Labor Gmbh；
    IPC主号:
    专利说明:

    The invention relates to a device for detecting the withdrawal of drugs from a medicament blister.
    Improper use of the drug is a major problem in practice. With the right diagnosis and optimal treatment plan, treatment success can be dramatically reduced if the patient is not using the drug properly. For some medications, such as anticoagulants, a wrong application can even have life-threatening consequences. The sources of error in practice are many: patients take no or the wrong medication, they take the right medication in too small or too high doses. The World Health Organization (WHO) estimates that every second patient does not stick to leaflets or medical instructions. Experts assume that in Germany every fourth hospital admission and many deaths - alone more than 40,000 per year in the indication "heart and circulation" - are due to an incorrect use of drugs. The reliable detection of the correct and regular medication intake by the patient, on the one hand health and on the other insurance reasons, therefore, is desirable, at least for certain classes of drugs.
    The currently existing approaches to detecting the removal of tablets from blister packs are only very limited suitable for the mass market and have not been enforced because they are too complex to handle and in production. These methods are based on the idea of destroying electrical tracks, antenna structures, components of resistor networks, etc. by squeezing out the tablets, which is easily detectable by electronics connected to these structures. For this purpose, these structures, such as printed conductors, antennas, resistor networks, etc., must either be integrated directly into the sealing film of the blister pack or applied subsequently to the sealing film, for example in the form of an adhesive film which contains the structures mentioned precisely for the respective blister.
    At present, smaller clinical studies are therefore based on the approach with subsequently printed on the underside of standard blisters accurately glued films containing the structures mentioned. By deliberately provided predetermined breaking points in the films it is pressed or torn in the course of the tablet removal together with the blister seal and the respective blister pack or tablet associated structural element, such as a trace, antenna, etc, destroyed or rendered inoperative. Via electronics associated with the structural elements, e.g. The date of the tablet removal and which tablet was removed can be recorded by means of a contact strip electrically connected to the foil.
    The main problem of these approaches is the fact that the detection of the removal of the tablets is based on the destruction of the foil which has been adhesively bonded to the blister with the structural elements. Therefore, for each blister, a new film with structural elements is needed, resulting in a linear increase in cost with the number of drug blisters needed. The alternative approach of integrating the structural elements already in the blister closure film is on the part of the drug manufacturer as production technically too complex, regulatory too complex and considered in terms of the cost of drug packaging as unacceptable.
    A solution with a reusable detection element for monitoring the removal of pills would therefore not only amortize very quickly, not only in the case of large studies or in mass application in the routine, but would also make the production of highly specialized blisters obsolete.
    It is therefore the object of the invention to simplify the detection of the tablet removal and to provide a device which makes the detection possible even if the tablet manufacturer has not provided such a possibility.
    The invention solves this problem in a device of the type mentioned above with the features of claim 1.
    An inventive device for detecting the removal of drugs from a drug blister comprises a base body for receiving the drug blister with a base, which is designed to rest against the pockets of the blister occlusive electrically conductive, in particular metallic, film, wherein the base body in the region of the pockets the blister holes which are formed for the passage of the drugs located in the pockets of the blister. Furthermore, it is provided that - each hole is arranged in the region of one of the pockets, - that in the region of each of the holes at least one coil is arranged, which wraps around the respective hole, in particular exclusively the respective hole, and - that a detector unit is provided which generates an electric and / or magnetic field by means of one of the coils in the region of one or more holes and which
    Voltage or the current to at least one of the hole, in particular exclusively this hole, looping coils evaluates.
    With such a device, it is possible in a simple manner to detect the removal of medicaments from the blister, without the blister having to have special features for this purpose.
    In a preferred device for detecting the removal of medicaments from a medicament blister, comprising a base body for receiving the medicament blister with a base surface, which is designed to abut against the pockets of the blister occluding electrically conductive, in particular metallic, film is advantageously provided that the base body in the region of the pockets of the blister has holes, which are formed for the passage of the drugs located in the pockets of the blister, - each hole is arranged in the region of one of the pockets, - wherein in each case a transmitting coil and at least two receiving coils are arranged, which wrap around the respective hole, and - wherein the receiving coil with respect to the transmitting coil associated with each other and are arranged such that in the event that in the region of the respective hole the main body adjacent foil intact, in particular free of Ri is the difference between the induced in the receiving coil according to an electric current in the transmitting coil voltages below a predetermined threshold.
    By this measure, a simple and easy to carry out detection of the opening of a pocket of a drug blister is possible.
    A possible development of the invention, which allows a precise detection, provides that a transmitting coil is present, which wraps around at least one of the holes, in particular all holes, and that in each case at least one receiving coil is arranged in the region of the holes, the respective hole , especially exclusively this hole, wraps around.
    A possible further development of the invention, which makes it possible to detect a crack with simple means, provides that in each case at least two receiving coils are arranged in the region of the holes, which loop around the respective hole, in particular exclusively this hole.
    A further improvement in the precision of the detection can be achieved if a separate transmission coil is present for each of the holes.
    The detection of a crack can be further simplified if the receiving coils are associated with each other with respect to the transmitting coil and arranged so that in the event that in the region of the respective hole the main body adjacent foil intact, in particular free of cracks, the difference of in the receiving coils according to an electric current in the transmitting coil induced voltages is below a predetermined threshold.
    An advantageous implementation of an automated detection can be achieved by a detector unit which activates the transmitting coil and measures the voltages at the receiving coils, and determines the difference between the voltages at the receiving coils and in the event that the difference between the two voltages a predetermined Threshold exceeds, and in this case gives a message indicating the presence of a crack in the metal bag closing the respective bag.
    A development of the invention with a simplified construction provides that the detector unit comprises: a control unit which activates the transmission coil, a measuring unit which measures the voltages at the reception coil or the reception coils, a reference value memory for storing all measured voltages at an initial time, in particular after a new, intact drug blister has been inserted into the device, and a comparison unit for determining the withdrawal of medicaments from the medicament blister, which respectively determines the difference between the voltage stored by the reference value accumulator and the voltage currently determined by the measuring unit, and, in the event that said difference exceeds a predetermined threshold, outputting a message indicating the presence of a tear in the region of the receiving coils in the metal foil closing the respective pocket.
    A simple detection of cracks can be achieved by the detector unit comprising: a control unit which activates the transmission coil, a measuring unit which measures the voltages at the receiving coils, and determines the voltage difference of these measured voltages, a reference value memory for storing all the determined voltages Voltage differences at an initial time, in particular after a new intact drug blister has been loaded into the device; and - a comparison unit for determining the withdrawal of drugs from the blister, each determining the difference between the voltage difference stored by the reference value memory and the voltage difference currently detected by the measurement unit and which, in the event that this difference exceeds a predetermined threshold, emits a message indicating the presence of a crack in the area of the receiving coils in the metal foil closing the respective pocket i ndiziert.
    A particularly simple embodiment of the invention provides that - for each hole, one, in particular exactly one, separate, loop is wrapped around the hole, - that the detector unit applies an electrical voltage to the coil and measures the current flowing through the coil electric current and from this the impedance of the coil and / or the possibly effective and reactance of the coil is determined, and that the detector unit detects the exceeding of a predetermined impedance threshold and / or predetermined thresholds for the active and reactive resistance of the coil, and in this case emits a message which indicates the presence of a crack in the region of the coil in the metal foil closing the respective pocket.
    In order to have the removal information available for further processing, it may be provided that a recording unit which activates the detector unit at predetermined time intervals and determines the presence of cracks in the films closing the pockets of the blister and stores the relevant information in a memory and for further queries available.
    A simple data exchange is ensured by a short-range radio module, comprising an antenna and a communication controller, is connected to the detector unit and - a memory in which upon detection of a crack in the film a related message, in particular additionally provided with a time stamp stored is provided is provided, wherein the detector unit can transmit stored information in the memory to an external data communication device.
    An advantageous data exchange via RFID / NFC becomes possible if the short-range radio module is an RFID or NFC transponder comprising a transponder antenna and a communication controller.
    In this case, it is advantageous to provide for simple and trouble-free transmission to an external data communication device that the transponder antenna runs at least partially along the outer boundary of the main body of the device.
    Alternatively, the short-range radio module may also operate on the basis of a Bluetooth standard, having an antenna and a communication controller.
    An advantageous evaluation of a pocket of a pharmaceutical blister provides that an excitation unit is provided, which is connected to the transmitting coil and two measuring units are provided, which are connected to the receiving coils, and the detector unit has a control unit which controls the excitation unit for exciting the transmitting coil and the measuring units for measuring the voltage applied to the receiving coils induction voltages, determines the difference of the determined induction voltages and in the event that the amount difference exceeds a predetermined threshold, emits a signal.
    A simple evaluation of a plurality of pockets of a pharmaceutical blister provides that the multiplexer is connected to the detector unit for the selection of a group comprising mutually associated transmit and receive coils, wherein the multiplexer has a common input for controlling the respective transmit antenna and two common outputs for Receiving received from the receiving coils induction voltages, wherein the common input to the excitation unit and the common outputs are each connected to one of the measuring units, the multiplexer comprises groups comprising two multiplex inputs and a multiplex output, which are jointly addressable and are each connected to the mutually associated and arranged in the region of the same hole transmitting and receiving antennas.
    A particularly accurate detection in a simple design is achieved by the receiving coils are arranged symmetrically with respect to the holes and with respect to the transmitting coil.
    A simple design provides that the detector unit and the short-range radio module are housed in a separate housing and the detector unit is electrically connected via non-destructively separable electrical contacts with the disposed on or in the base body transmitting antennas and receiving antennas.
    Also particularly advantageous is an arrangement comprising a device according to the invention as well as a drug blister with a number of pockets adjacent to the holes and containing a medicament and a pocket closing foil which bears against the base surface, each hole comprising a group comprising a transmitting coil and at least two receiving coils opposite.
    Several preferred embodiments of the invention will be further illustrated by the following drawing figures.
    Fig. 1 shows a first embodiment of a device for detecting the withdrawal of drugs and a drug blister. Fig. 2 shows the device shown in Fig. 1, wherein the medicament blister is inserted into the device. Fig. 3 shows the combination shown in Fig. 2 comprising the device and the medicament blister in cross-section. Fig. 4 shows a detail of Fig. 3. Fig. 5 shows a circuit and an arrangement of transmitting and receiving coils. Fig. 6 shows the embedding of the transmitting and receiving coils shown in Fig. 5 in the device for detecting the withdrawal of drugs. 7 shows the field conditions in the region of a pocket of the medicament container in a sectional view. 8 shows a section through the blister and the profile of the proportion of the field strength or flux density of the magnetic field created by the transmitting coil or its proportion normal to the foil of the blister. 9 shows in detail the field conditions in the region of an unopened and intact medicine bag as well as the activation and readout of the transmitting and receiving coils. 10 shows in detail the field conditions in the region of an opened and torn medicament bag as well as the control and the readout of the transmitting and receiving coils. 11 shows a diagram of the voltage measurement values as well as the threshold values for the detection. Fig. 12 shows schematically the electronic measurement or detection of the withdrawal of drugs.
    FIGS. 13 to 15 show alternative coil arrangements with a transmitting coil and two or three receiving coils.
    16 to 19 show devices according to a second embodiment of the invention with one or more common transmitting coils and two receiving coils per hole. FIG. 20 shows the field conditions in the region of a pocket of the medicament container in a sectional representation in a device as shown in FIGS. 16 to 19. Fig. 21 shows a graph of the voltage measurement values as well as the thresholds for the detection. Fig. 22 schematically shows the electronic measurement in one of the embodiments of the invention shown in Figs. 16 to 21.
    Fig. 23 shows another embodiment of the invention with a single coil per hole. Fig. 24 schematically shows the electronic measurement in one embodiment of the invention shown in Fig. 23.
    In Fig. 1, a first embodiment of a device according to the invention for detecting the removal of drugs 23 from a drug blister 2 is shown. The device 1 has a base body 10 with an opening 101 for insertion of the medicament blister 2 into the base body 10. At the position at which the medicaments 23 containing pockets 21 of the blister 2 are located, the base body 10 of the device 1 each have holes 12 , The pockets 21 are thus directly opposite the holes 12, so that the medicaments 23 located in the pockets 21 of the blister 2 can be removed from the pockets 21 through the holes 12 from the blister 2 or from the device 1.
    FIG. 2 shows the drug blister 2 pushed through the opening 101. FIG.
    In Fig. 3, the combination of the device for detecting the withdrawal of drugs 23 with the drug blister 2 is shown in side view. FIG. 4 shows the detail A from FIG. 3. The region of the remaining pockets is formed around the pocket 21 as well as the area shown in detail A. FIG. The pocket 21 represents a bulge of the medicament blister 2 in which the medicament 23 to be withdrawn, which in the present case is designed as a tablet 23, is located. The pocket 21 is coated on the planar continuation of the body of the medicament blister 2 with an electrically conductive film 22 which closes the pocket 21, wherein the film 22 contains or consists of at least one planar continuous, electrically conductive layer. In the region of the pocket there are three coils, namely a transmitting coil 13 and two receiving coils 14, 15.
    In Fig. 5, the electronic and electrical components of the device are shown. Fig. 5 shows a total of ten groups 19a ... 19j of mutually associated transmit coils 13a ... 13j and receive coils 14a ... 14j, 15a ... 15j. Each group 19a... 19j determines the opening of each of the pockets 21 of the blister 2. FIG. 5 also shows an electronic circuit 102 which implements a control unit 160 or detector unit 16 (FIG. 12) and a voltage supply 103.
    Fig. 6 shows the device with its housing in which the transmitting and receiving coils 13, 14, 15 shown in Fig. 5 are arranged, in particular cast or printed. Furthermore, an additional transmitting antenna 191 is shown in FIG. 6, by means of which the data determined in connection with the withdrawal of the medicament can be transmitted to an external data communication device. In the present exemplary embodiment, the transmitting antenna 191 runs along the outer boundary of the main body 10 of the device 1.
    In this configuration and when the sealing film 22 is intact, as shown in FIG. 9, the eddy currents lw induced in the electrically conductive layer of the sealing foil due to the magnetic field generated by the transmitting antenna 13 are distributed in the area of the pocket 21. Due to the respective flux linkages, The two receiving coils 14, 15 each have an induction voltage VA, VB, which is determined by the measuring devices 166, 167 and forwarded to a control unit 160.
    In Fig. 7, the field and current distribution at unopened bag 21 and undamaged film 22 in the region of the bag is shown. Fig. 7 shows in section the arrangement of the transmitting coil 13 and the two receiving coils 14, 15, which wrap around the hole 12 of the base body 10 of the device 1. Above the hole 12, the bag 21, closing the film 22 is shown. Due to the excitation in the transmitting coil 13, in the absence of the foil 22 in the region of the hole 12, an undisturbed magnetic field BT would arise. Due to the eddy currents lw induced in the foil 22, however, an opposing field Bw is created which, when superimposed with the excitation field BT, results in a resulting field Bres which is considerably weakened compared to the originally exciting field BT.
    Fig. 8 shows a curve of the magnetic field created by the transmitting antenna 13, e.g. the magnetic field strength H or the magnetic flux density B, over the coordinate direction x and the device 1 and the blister 2 in section. The course of the field strength H is symmetrical with respect to the hole 12, i. no matter from which position of the transmitting antenna 13 one approaches the center of the hole 12, there is always the same magnetic field intensity or flux density profile. The induction voltage determined at the receiving antennas 14, 15 is in each case proportional to the integral among the respective flux density curves or their time derivative. From Fig. 8, it can be seen that the flux concatenated with the two receiver coils 14, 15, i. the integrally shaded integral of the flux density B over the area looped by the receiving coil 14, 15 is the same, and the difference AV = (VA-VB) of the two induction voltages VA present at the receiving coils 14, 15 is accordingly the same for intact foil 22 of the blister 2, VB is zero.
    If the film 22 occluding the pocket 21 tears open, the eddy currents induced in the film 22 underneath the pocket 21 are distributed irregularly.
    FIG. 10 shows a current configuration of eddy currents lw, the foil 22 being torn in the region of the pocket 21. Due to the different orientation and size of the residues of the film 22 resulting from the crack, different voltages VA, VB are induced in the two receiving coils 14, 15, which voltages are perceived by the voltage measuring devices 166, 167. The control unit 160 in this case detects a voltage difference AV and accordingly outputs a recognition message 173 indicating the detection of the rupture or removal of the medicament 23. Particularly large and therefore easily detectable voltage differences are caused by the fact that in practice, the resulting after tearing of the film 22 film residues underneath the pocket 21 at least slightly or partially out of the plane of the film 22. As a result, the eddy currents induced in these film residues no longer flow in the plane of the film 22, which leads to a complex three-dimensional distribution of the resulting magnetic field Bres, which deviates significantly from the magnetic field distribution when the closure film 22 is intact.
    FIG. 11 shows a diagram in which the difference AV = (VA-VB) of the voltage measurement values VA, VB is plotted against the two receiver coils 14, 15 over time, wherein at a time tR the foil 22 of the blister 2 is in the region of Receiving coils 14, 15 and the hole 12 is torn open. Due to the shape of the crack, which is never exactly symmetrical, the field conditions in the area of the receiving coils 14, 15 change so that one of the receiving coils 14, 15 is associated with a larger or smaller magnetic flux emitted by the transmitting coil 13. This circumstance can be determined by the detector unit 16 shown in FIG. In the present case, the amount of the difference of the voltages VA, VB at the receiving coils 14, 15 increases from a first voltage difference value AV1; which is almost zero, to a voltage difference value ΔV2 exceeding a predetermined threshold AVT. Due to this exceeding the threshold value AVT, it can be concluded that there is a crack in the film 22 of the blister 2.
    FIG. 12 shows a detector unit 16 with which the removal of a large number of medicaments 23 from pockets in the same medicament blister 2 can be detected. In this case, the detector unit 16 has the control unit 160 and a multiplexer 161 for the selection of the respective group 19a... 19j, each comprising mutually assigned transmitting and receiving coils 13a... 13j, 14a... 14j and 15a , The multiplexer has a common input 163 for controlling the respective transmission antenna 13. This terminal is connected to the voltage generator 162, which is controlled by the control unit 160. Furthermore, the multiplexer 161 has two common outputs 164, 165, which are each assigned to one of the voltage measuring devices 166, 167. The results of the voltage measurement are transmitted from the voltage measuring devices 166, 167 to the control unit 160. The control unit 160 further establishes, via the multiplex control output 175, the respective group of transmitting and receiving coils 13a, 14a, 15a ... 13j, 14j, 15j which are respectively addressed to determine whether or not the respective medicament 23 is associated with the respective one Bag 21 a ... 21 j was removed. The multiplexer 161 comprises in groups each two multiplex inputs 170a, 171a ... 170j, 171j and a multiplex output 172a ... 172j, each of the groups being separately addressable. The multiplexed inputs and multiplexed outputs associated with each other in groups 19a... 19j are each provided with transmit and receive antennas 13a... 13j... 13j... 14j... 14j, 15a, which are associated with one another and grouped in the area of the same hole 12. 15j connected.
    In order to detect whether the metal foil 22 resting against the base body 10 in the region of the respective hole 12 is intact, in particular free of cracks, the difference between the voltage induced in the receiving coil 14, 15 according to an electrical current in the transmitting coil 13 is measured. If this is below a predetermined threshold value, then the film 22 in the region of the respective hole 12 can be regarded as intact.
    The detector unit 16 measures the two voltages applied to the receiver coils 14, 15 and determines the difference between the voltages at the receiver coils 14, 15. In the event that the difference between the two voltages exceeds a predetermined threshold value, it outputs a message which indicates the presence of a crack in the metal foil 22 closing the respective pocket 21.
    In order to enable communication with an external data communication device, the control unit 160 is connected to a short-distance radio module 190 comprising an antenna 191 and a communication controller 192. This short-range wireless module can be either an RFID or NFC transponder as well as another short-range wireless communication technique, such as e.g. Bluetooth act. Furthermore, the control unit 160 is connected to a memory 18, wherein the control unit 160 in detection of the removal of a drug 23 from one of the pockets each stores a message in the memory 18 and holds it available for retrieval by an external data communication device.
    In particular, the detector unit 16 and the short-range radio module 190 can also be accommodated in a separate housing and the detector unit 16 is electrically connected to the transmitting antennas 13 and receiving antennas 14, 15 arranged on or in the main body 10 via non-destructively separable electrical contacts.
    Furthermore, FIG. 12 shows a recording unit 17 which triggers the recording of the withdrawal of medicaments at predetermined time intervals. The recorded values or messages, which represent the withdrawal of medicaments, are stored in the memory 18.
    FIG. 13 shows an alternative embodiment of the arrangement of transmitting and receiving coils. This particular arrangement comprises a transmitting coil 13 and three receiving coils 14, 15, 15 ', all of which are circular. The centers, the receiving coils 14, 15, 15 'are located on an equilateral triangle, in the center of gravity of the center of the transmitting coil 13 is located. Furthermore, the edge 220 of the pocket 21 on which the film 22 adjoins is formed concentrically with the transmitting coil 13.
    FIGS. 14 and 15 show further alternative coil arrangements with a transmitting coil 13 and two or three receiving coils 14, 15, 15 ', the transmitting coil in this case completely enclosing the receiving coils.
    FIG. 16 shows a further device 3 according to a second embodiment of the invention. This device 3, like the device 1 shown above, has a number of holes 32a-32j surrounded by a transmitting coil 33 and receiving coils 34a ... 34j, 35a ... 35j. However, unlike the device 1 according to the first embodiment of the invention, the device 3 does not have a transmitting coil 33a ... 33j per hole 32a ... 32j but only a single transmitting coil 33 for all the holes 32a ... 32j. The transmitting coil 33 shown in FIG. 16 wraps and surrounds all the receiving coils 34a... 34j, 35a... 35j whose arrangement corresponds to the arrangement of the receiving coils 34a... 34j, 35a... 35j of the device 1 according to the first embodiment of FIG Invention corresponds, ie in each case two mutually associated receiving coils 34a, 35a,..., 34j, 35j are arranged in the area in each case one of the holes 32a ... 32j.
    FIGS. 17 to 19 show minor modifications of the further device 3, which instead of a single transmitting coil 33 each comprise a plurality of transmitting coils 33, each looping around a subset of the receiving coils 34a... 34j, 35a... 35j, all of the transmitting coils 33 in total all receiving coils 34a ... 34j, 35a ... 35j wrap around and each pair of associated receiving coils 34a ... 34j, 35a ... 35j are respectively looped by exactly one of the transmitting coils 33.
    In Fig. 20, a representation analogous to Fig. 8 is shown, showing a curve representing the magnetic field created by the transmitting antenna 33, e.g. in the form of the magnetic field strength H or the magnetic flux density B in the region of a hole 32. However, the course of the field strength H or the flux density B is not symmetrical with respect to the hole 32. The induction voltage VA, VB determined at the receiving antennas 34, 35 is in each case proportional to the integral among the respective flux density curves or their time derivative. From Fig. 20 it follows that the flux coupled to the two receiving coils 34, 35, i. the integral of the flux density over the looped surface is not the same for the two receiver coils 34, 35 when the foil 22 of the blister 2 is intact and accordingly the difference between the two voltage VA - VB applied to the receiver coil 34, 35 is not equal to zero.
    If the film 22 occluding the pocket 21 tears open, the eddy currents induced in the film 22 underneath the pocket 21 are distributed differently and the determined voltage difference VA - VB changes.
    21 shows a diagram in which the difference AV of the voltage measurement values VA, VB is plotted against the two receiver coils 34, 35 over time, wherein at a time tR the film 22 of the blister 2 in the region of the receiver coils 34, 35 or of the hole 32 is torn open. Already due to the asymmetrical arrangement of the two receiving coils 34, 35 with respect to the transmitting coil, which is shown in Fig. 20, results in intact film 22, a non-zero voltage difference .DELTA.V. This voltage difference .DELTA.V intact film is cached as a reference voltage difference AVinit and kept available for further comparisons.
    If a crack occurs in the foil 22 at the time tR, the field conditions in the region of the receiving coils 34, 35 also change so that one of the receiving coils 34, 35 is associated with a larger or smaller magnetic flux emanating from the transmitting coil 33. This circumstance can be determined by the detector unit 360 shown in FIG. 22. In the present case, the amount of the difference AM of the voltages VA, VB at the receiving coils 34, 35 from the reference voltage difference AVmn increases or decreases to a larger or smaller voltage difference value. In order to detect such deviations, the determined voltage difference values are compared with two threshold values A fmin and AVmax. If the respective voltage difference value AM is within the interval defined by the two threshold values AVmin, AVmax, the foil 22 of the blister 2 is considered to be intact; otherwise, the film 22 is considered cracked and an appropriate message issued.
    FIG. 22 shows the electronic measurement or the electronic determination of a crack by means of a device 3 according to the second embodiment of the invention, the measurement shown substantially corresponding to the measuring device illustrated in FIG. 12. FIG. 22 shows a detector unit 36 with which the removal of a plurality of medicaments 23 from pockets 21 of the same medicament blister 2 can be detected. In this case, the detector unit 36 has the control unit 360, which controls the sequence of the measurement. The transmitting coil 33 is directly connected to the voltage generator 362, which is controlled by the control unit 360.
    The detector unit 36 furthermore has a multiplexer 361 for the selection of the respective group 39a... 39j, comprising in each case mutually associated receiver coils 34a... 34j and 35a... 35j. The multiplexer 361 has two common outputs 364, 365, each associated with one of the voltage measurement units 366, 367. The results VA, VB of the voltage measurement are transmitted from the voltage measuring devices 366, 367 to the control unit 360.
    The control unit 360 further determines, via the multiplex control output 375, the respective group of receiving coils 34a... 34j, 35a... 35j, which are respectively addressed to determine whether the respective medicament 23 from the respective associated pocket 21a .. .21 j was taken. Multiplexer 361 comprises two multiplex inputs 370a, 371a ... 370j, 371j, each comprising groups, each of which is separately addressable. The multiplex inputs, which are assigned to one another in groups 19a... 19j, are each connected to receiving coils 14a... 14j... 15j... 15j assigned to one another and grouped and arranged in the region of the same hole 12.
    To improve the detection accuracy can be determined before the actual detection of cracks with each of the individual receiving coils 34a ... 34j, 35a ... 35j, how large the respective induced voltage VA, VB in an intact or original blister 2 with intact film 22 is when a predetermined AC voltage is applied to the transmitting coil 33. The voltage values VA, VB or the difference AVinit of the voltages of each of two associated receiver coils 34a, 35a,..., 34j, 35j determined by the individual receiver coils 34a... 34j, 35a... 35j are hereby stored in a reference value memory 397 stored and kept available for later comparison.
    In order to detect whether the metal foil 22 which bears against the base body 30 in the region of the respective hole 32 is intact, in particular free of cracks, the difference AV of the voltages present in the receiving coils 34, 35 is measured. Subsequently, the comparison difference 396 compares the measured difference AV with the reference voltage difference AVinit stored in the reference value memory 397 for the respective receiving coils. Alternatively, the comparison difference 396 can also be used to compare the measured difference AV with the difference AVinit of the reference voltage measured values determined in the reference value memory 397 for the respective receiver coils. If the voltage difference AV deviates from the reference voltage difference AVinit by a predetermined threshold value, a crack is considered to be detected. For this purpose, as shown in Fig. 22, respectively, the determined
    Voltage difference AV and the reference voltage difference AVinit from the comparison unit 396 compared. If the voltage difference AV lies within an interval around the reference voltage difference ΔVinit with the upper limit Vmax and the lower limit Vmin, the foil 22 is considered to be intact in the region of the respective hole 32, otherwise torn.
    In order to enable communication with an external data communication device, the control unit 360 is connected to a short-distance radio module 390 comprising an antenna 391 and a communication controller 392. This short-range wireless module can be either an RFID or NFC transponder as well as another short-range wireless communication technique, such as e.g. Bluetooth act. Furthermore, the control unit 360 is connected to a memory 38, wherein the control unit 360, upon detection of the removal of a medicament 23 from one of the pockets, stores a respective message in the memory 38 and keeps it available for retrieval by an external data communication device.
    In particular, the detector unit 36 and the short-range radio module 390 can also be accommodated in a separate housing and the detector unit 36 is electrically connected to the transmitting antennas 33 and receiving antennas 34, 35 arranged on or in the main body 30 via non-destructively separable electrical contacts.
    Furthermore, in Fig. 22, a recording unit 37 is shown, which triggers the recording of the withdrawal of drugs at predetermined time intervals. The recorded values or messages, which represent the withdrawal of medicaments, are stored in the memory 38.
    Fig. 23 shows another device 4 according to a third embodiment of the invention with a single coil 43a ... 43j per hole 42a ... 42j. The respective coil 43 serves both as a transmitting and as a receiving coil. By determining the respective inductance or impedance of the coil 43, which in addition to the coil geometry also depends substantially on the media located in the region of the coil 43, it can be determined whether the film 22 of the blister 2 has broken in the region of the coil 43.
    FIG. 24 schematically shows the electronic measurement in one of the apparatuses 4 shown in FIG. 23. The illustrated apparatus 4 substantially corresponds to the measuring apparatus shown in FIG. With the detector unit 46, the removal of a plurality of drugs 23 from pockets 21 of the same drug blister 2 can be detected. In this case, the detector unit 46 has the control unit 460, which controls the sequence of the measurement.
    The detector unit 46 further has a multiplexer 461 for selecting the respective coil 43a ... 43j. The multiplexer 461 has a common bipolar output 463 connected to the voltage generator 462. In one of the connecting lines between the voltage generator 462 and the common input 463 of the multiplexer 461, a current measuring device 466 is arranged. Both the voltage 462 present at the voltage generator 462 and the current determined by the current measuring device 466 are supplied to the control unit 460.
    The control unit 460 sets further via the multiplex control output 475, the respective coil 43a ... 43j, which are each addressed to determine whether the respective drug 23 has been removed from the respective associated pocket 21 a ... 21 j. Multiplexer 461 has two-pole multiplexed ports 470a... 470j, each coil 43a... 43j being separately addressable.
    In order to improve the detection accuracy, before the actual detection of cracks with each of the individual coils 43a... 43j, it can be determined how large the respective impedance of the coil 43a... 43j is with an intact film 22 with an intact or original blister 2 , The voltages applied to the individual coils 43a... 43j and the currents respectively determined by the current measuring device 466 are related to one another and the determined impedance, for example with its real and imaginary part or with its magnitude and phase, in a reference value memory 497 stored as reference impedance for a later comparison.
    In order to detect whether the metallic foil 22 lying in the region of the respective hole 32 is intact, in particular free of cracks, the impedance of the respective coil 13a... 13j is determined and the impedance thus determined with the reference impedance stored in the reference value memory 497 compared by a comparison unit 496. The respective deviation of the real part and the imaginary part or the phase and the amount is determined and compared with a threshold value. If the deviation exceeds the threshold value, it is assumed that the metallic foil 22 of the blister 2 has broken and a corresponding message 473 is issued.
    In order to enable communication with an external data communication device, the control unit 460 is connected to a short-range radio module 490 comprising an antenna 491 and a communication controller 492. This short-range wireless module can be either an RFID or NFC transponder as well as another short-range wireless communication technique, such as e.g. Bluetooth act. Furthermore, the control unit 460 is connected to a memory 38, the control unit 460, upon detection of the removal of a medicament 23 from one of the pockets, stores a respective message in the memory 38 and keeps it available for retrieval by an external data communication device.
    The detector unit 46 and the short-range radio module 490 can in particular also be accommodated in a separate housing and the detector unit 46 is connected via non-destructively separable electrical contacts with the antennas 43a..43j arranged on or in the main body.
    Furthermore, in Fig. 24, a recording unit 47 is shown, which triggers the recording of the withdrawal of drugs at predetermined time intervals. The recorded values or messages, which represent the withdrawal of medicaments, are stored in the memory 48.
    In all embodiments, one or more measuring frequencies in the frequency range between 100 Hz and 100 MHz is used to control the coil.
    权利要求:
    Claims (19)
    [1]
    Claims 1. A device (1; 3; 4) for detecting the withdrawal of medicaments (23) from a medicament blister (2), comprising a main body (10) for receiving the medicament blister (2) with a base (11) which is intended for Attachment to which the pockets (21) of the blister (2) closing electrically conductive, in particular metallic, film (22) is formed, wherein the base body (10) in the region of the pockets (21) of the blister (2) holes (12; 42), which are designed for the passage of the in the pockets (21) of the blister (2) located drugs (23), - wherein each hole (12) respectively in the region of one of the pockets (21) is arranged, - in the region of each of the holes (12) at least one coil (13, 14, 15; 33, 34, 35, 43) is arranged, which wraps around the respective hole (12), in particular exclusively the respective hole (12), and wherein a detector unit (16; 36; 46) is provided, which by means of one of the coils (13, 14, 15) in the area ch one or more holes (12) generates an electric and / or magnetic field and the voltage or the current to at least one of the hole (12), in particular exclusively this hole (12), looping around coils (13, 14, 15) evaluates ,
    [2]
    2. Apparatus according to claim 1, characterized in that a transmitting coil (13) is present, at least one of the holes (12), in particular all holes (12), wraps around, and that in the region of the holes (12) each have at least one receiving coil (14, 15) is arranged, which wraps around the respective hole (12), in particular exclusively this hole (12).
    [3]
    3. Device according to claim 1 or 2, characterized in that in the region of the holes (12) in each case at least two receiving coils (14, 15) are arranged, which loop around the respective hole (12), in particular exclusively this hole (12).
    [4]
    4. Device according to one of the preceding claims, characterized in that for each of the holes (12) each have a separate transmitting coil (13) is present.
    [5]
    5. Device according to claims 3 and 4, characterized in that the receiving coils (14, 15) with respect to the transmitting coil (12) associated with each other and arranged such that in the event that in the region of the respective hole (12) the Main body (10) adjacent film (22) is intact, in particular free of cracks, the difference in the receiving coils (14,15) due to an electric current in the transmitting coil (13) induced voltages below a predetermined threshold.
    [6]
    6. The device according to claim 5, characterized in that the detector unit (16) activates the transmitter coil (13) and measures the voltages at the receiver coils (14, 15), and determines the difference between the voltages at the receiver coils (14, 15) and in the event that the difference between the two voltages exceeds a predetermined threshold value, a message indicating the presence of a crack in the region of the receiving coils (14, 15) in the metal foil (22) closing off the respective pocket (21) is output.
    [7]
    7. Device according to one of claims 1 to 4, characterized in that the detector unit (36), comprising: - a control unit (360) which activates the transmitting coil (33), - a measuring unit (366, 367), the Voltages (VA, VB) at the receiving coil (34) or the receiving coils (34, 35) measures, - a reference value memory (397) for storing all measured voltages (VA, VB) at an initial time, in particular after a new, undamaged drug blister (2 ) was inserted into the device, and - a comparison unit (396) for detecting the withdrawal of drugs from the drug blister (2), each of the difference between the voltage stored by the reference value memory (397) and the voltage from the measuring unit (366, 367) currently detected voltage, and, in the event that this difference exceeds a predetermined threshold, emits a message indicating the presence of a crack in the receiving coil (34,35) in the respective bag (21) occluding metal foil (22) indicated.
    [8]
    Device (3) according to one of Claims 1 to 4, characterized in that the detector unit (36) comprises: - a control unit (360) which activates the transmission coil (33), - a measuring unit (366, 367) measures the voltages at the receiving coils (34, 35), and the voltage difference (AV) of these measured voltages determines a reference value memory (397) for storing all the determined voltage differences (AVinit) at an initial time, in particular after a new unimpaired medicament blister (2) is in the device (3) has been inserted, and - a comparison unit (396) for determining the withdrawal of medicaments from the blister (2), each of which determines the difference between the voltage difference (AVinit) stored by the reference value memory (397) and that of the measuring unit (39) 366, 367) currently determined voltage difference (AV) and which, in the case that this difference exceeds a predetermined threshold, a message which indicates the presence of a crack in the region of the receiving coils (34, 35) in the metal foil (22) closing the respective pocket (21).
    [9]
    9. Device (4) according to one of the preceding claims, characterized in that - for each hole (42) one, in particular exactly one, separate hole (42) looping around coil (43) is provided, - that the detector unit ( 46) applies an electrical voltage to the coil (43) and measures the electrical current flowing through the coil (43) and determines therefrom the impedance of the coil (43) and / or the potential and reactance of the coil (43), and - That the detector unit (46) detects the exceeding of a predetermined impedance threshold and / or predetermined thresholds for the reactance and reactance of the coil (43), and in this case emits a message indicating the presence of a crack in the region of the coil (43) in which the respective pocket (21) occluding metal foil (22) indicated.
    [10]
    10. Device (1) according to one of the preceding claims, characterized by a recording unit (17) which activates the detector unit (16) at predetermined time intervals and the presence of cracks in the pockets (21) of the blister (2) closing films ( 22) and stores the relevant information in a memory (18) and keeps it available for further queries.
    [11]
    11. Device (1) according to one of the preceding claims, characterized by - a short-range radio module (190) comprising an antenna (191) and a communication controller (192) which is connected to the detector unit (16) and - a memory ( 18), in which upon detection of a crack in the film (22) a relevant message, in particular additionally provided with a time stamp, is stored, wherein the detector unit (16) in the memory (18) transfers stored information to an external data communication device.
    [12]
    12. Device (1) according to claim 11, characterized in that the short-range radio module (190) is an RFID or NFC transponder comprising a transponder antenna (191) and a communication controller (192).
    [13]
    13. Device (1) according to claim 12, characterized in that the transponder antenna (191) extends at least partially along the outer boundary of the base body (10) of the device (1).
    [14]
    14. Device (1) according to claim 12, characterized in that the short-distance radio module (190), comprising an antenna (191) and a communication controller (192), operates on the basis of a Bluetooth standard.
    [15]
    15. Device (1) according to one of the preceding claims, characterized in that an excitation unit (162) is provided, which is connected to the transmitting coil (13) and two measuring units (166, 167) are provided which to the receiving coils (14 , 15), and the detector unit (16) has a control unit (160) which activates the excitation unit (162) for exciting the transmitting coils (13) and the measuring units (166, 167) for measuring the signals at the receiving coils (14, 15) actuates applied induction voltages, determines the difference between the determined induction voltages and emits a signal in the event that the magnitude of the difference exceeds a predetermined threshold value.
    [16]
    16. Device (1) according to one of the preceding claims, characterized in that the detector unit (16) comprises a multiplexer (161) for selecting a group (19) comprising respective mutually associated transmitting and receiving coils (13, 14, 15) is connected, wherein the multiplexer (161) has a common input (163) for driving the respective transmitting antenna (13) and two common outputs (164, 165) for obtaining the induction voltages obtained from the receiving coils, wherein the common input (163) to the excitation unit (162) and the common outputs (164, 165) are respectively connected to one of the measuring units (166, 167), the multiplexer (161) comprising groups each comprising two multiplex inputs (170a, 171a, ... 170j, 171 j) and a multiplex output (172a ... 172j) which are jointly addressable and in each case with the mutually associated and in the region of the same hole (12) arranged transmitting and receiving antennas (13, 14, 15) ve are bound.
    [17]
    17. Device (1) according to one of the preceding claims, characterized in that the receiving coils (14,15) are arranged symmetrically with respect to the holes (12) and with respect to the transmitting coil (13).
    [18]
    18. Device (1) according to one of the preceding claims, characterized in that the detector unit (16), and optionally the short-range radio module (190) are housed in a separate housing and the detector unit (16) via non-destructively separable electrical contacts with the on or in the base body (10) arranged transmitting antenna (13) and receiving antennas (14,15) is electrically connected.
    [19]
    19. Arrangement comprising a device (1) according to one of the preceding claims and a medicament blister (2) with a number of at the holes (12) adjacent and each containing a drug (23) containing pockets (21) and one of the pockets (21) closing film (22), which rests against the base surface (11), wherein in particular each hole (12) in each case a group comprising a transmitting coil (13) and at least two receiving coils (14, 15) is opposite.
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    同族专利:
    公开号 | 公开日
    US9833385B2|2017-12-05|
    US9931278B2|2018-04-03|
    ES2659426T3|2018-03-15|
    CA2939234A1|2015-08-20|
    DK3104822T3|2018-03-05|
    US20170172851A1|2017-06-22|
    EP3104823A1|2016-12-21|
    WO2015120497A1|2015-08-20|
    CA2939232A1|2015-08-20|
    AT515453A3|2016-05-15|
    EP3104822A1|2016-12-21|
    AT515453B1|2016-05-15|
    US20170165151A1|2017-06-15|
    DK3104823T3|2018-03-05|
    ES2659425T3|2018-03-15|
    EP3104823B1|2017-11-22|
    WO2015120498A1|2015-08-20|
    EP3104822B1|2017-11-22|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    ATA50103/2014A|AT515351B1|2014-02-11|2014-02-11|Device for detecting the withdrawal of drugs|
    ATA50173/2014A|AT515453B1|2014-02-11|2014-03-10|Device for detecting the withdrawal of drugs|ATA50173/2014A| AT515453B1|2014-02-11|2014-03-10|Device for detecting the withdrawal of drugs|
    US15/118,187| US9833385B2|2014-02-11|2015-02-02|Device for detecting the removal of drugs|
    EP15711638.5A| EP3104822B1|2014-02-11|2015-02-02|Device for detecting the removal of drugs|
    US15/118,185| US9931278B2|2014-02-11|2015-02-02|Device for detecting the removal of drugs|
    ES15711639.3T| ES2659426T3|2014-02-11|2015-02-02|Device for detecting drug withdrawal|
    ES15711638.5T| ES2659425T3|2014-02-11|2015-02-02|Device for the detection of drug extraction from a pharmaceutical blister|
    PCT/AT2015/050034| WO2015120498A1|2014-02-11|2015-02-02|Device for detecting the removal of drugs|
    DK15711639.3T| DK3104823T3|2014-02-11|2015-02-02|DEVICE FOR DISPOSAL OF REMOVAL OF MEDICINAL PRODUCTS|
    CA2939234A| CA2939234A1|2014-02-11|2015-02-02|Device for detecting the removal of drugs|
    CA2939232A| CA2939232A1|2014-02-11|2015-02-02|Device for detecting the removal of drugs|
    EP15711639.3A| EP3104823B1|2014-02-11|2015-02-02|Device for detecting the removal of drugs|
    PCT/AT2015/050033| WO2015120497A1|2014-02-11|2015-02-02|Device for detecting the removal of drugs|
    DK15711638.5T| DK3104822T3|2014-02-11|2015-02-02|DEVICE FOR DISPOSAL OF REMOVAL OF MEDICINAL PRODUCTS|
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